[HTML][HTML] The concept of folic acid in health and disease

Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Advances in lung cancer treatment using nanomedicines

A Sharma, D Shambhwani, S Pandey, J Singh… - ACS …, 2022 - ACS Publications
Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor
prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of …

[HTML][HTML] Targeting folate receptor alpha for cancer treatment

A Cheung, HJ Bax, DH Josephs, KM Ilieva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

Smart targeting to improve cancer therapeutics

M Morales-Cruz, Y Delgado, B Castillo… - Drug design …, 2019 - Taylor & Francis
Cancer is the second largest cause of death worldwide with the number of new cancer
cases predicted to grow significantly in the next decades. Biotechnology and medicine can …

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping

Z Zheng, Z Li, C Xu, B Guo, P Guo - Journal of Controlled Release, 2019 - Elsevier
Folate (FA) receptor is a cell surface glycoprotein overexpressed on many cancer cells. It is
a high affinity ligand for cancer cell targeting. However, delivery of siRNA directly through …

[HTML][HTML] Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

HJ Bax, J Chauhan, C Stavraka, A Santaolalla… - British Journal of …, 2023 - nature.com
Background Survival rates for ovarian cancer remain poor, and monitoring and prediction of
therapeutic response may benefit from additional markers. Ovarian cancers frequently …

New folate-grafted chitosan derivative to improve delivery of paclitaxel-loaded solid lipid nanoparticles for lung tumor therapy by inhalation

R Rosiere, M Van Woensel, M Gelbcke… - Molecular …, 2018 - ACS Publications
Inhaled chemotherapy for the treatment of lung tumors requires that drug delivery systems
improve selectivity for cancer cells and tumor penetration and allow sufficient lung …

[HTML][HTML] Targeted oral delivery of paclitaxel using colostrum-derived exosomes

R Kandimalla, F Aqil, SS Alhakeem, J Jeyabalan… - Cancers, 2021 - mdpi.com
Simple Summary Paclitaxel (PAC) is a widely used antitumor agent in the treatment of
various early-stage and advanced cancers, including lung cancer. While efficacious, solvent …

Bioadhesive chitosan nanoparticles: dual targeting and pharmacokinetic aspects for advanced lung cancer treatment

MK Viswanadh, AK Mehata, V Sharma, V Priya… - Carbohydrate …, 2021 - Elsevier
The chitosan-folate conjugate was synthesized initially and confirmed by FTIR and NMR
spectroscopic studies. Following, docetaxel (DXL) loaded non-targeted, single receptor and …

X‐Ray‐Responsive zeolitic imidazolate framework‐capped nanotherapeutics for cervical cancer‐targeting radiosensitization

S Pan, G Huang, Z Sun, X Chen… - Advanced Functional …, 2023 - Wiley Online Library
Developing radiosensitizers based on the characteristics of the tumor microenvironment can
improve the effectiveness and overcome the bottleneck of cervical cancer radiotherapy …