Proteolysis targeting chimeras (PROTACs) are heterobifunctional ligands that mediate the
interaction between a protein target and an E3 ligase, resulting in a ternary complex, whose …

Vicilins are related to cowpea seed resistance toward Callosobruchus maculatus due to
their ability to bind to chitinous structures lining larval midgut. However, this binding …

Motivation The successful application of deep learning has promoted progress in protein
model quality assessment. How to use model quality assessment to further improve the …

Protein structures play a very important role in biomedical research, especially in drug
discovery and design, which require accurate protein structures in advance. However …

VoroContacts is a versatile tool for computing and analyzing contact surface areas (CSAs)
and solvent accessible surface areas (SASAs) for three-dimensional (3D) structures of …

The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-
terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N-terminal kinases …

Molecular replacement (MR) is the predominant route to solution of the phase problem in
macromolecular crystallography. Where the lack of a suitable homologue precludes …

Geometric deep learning has recently achieved great success in non-Euclidean domains,
and learning on 3D structures of large biomolecules is emerging as a distinct research area …

Assessing the accuracy of 3D models has become a keystone in the protein structure
prediction field. ModFOLD7 is our leading resource for Estimates of Model Accuracy (EMA) …

Processing information on three-dimensional (3D) objects requires methods stable to rigid-
body transformations, in particular rotations, of the input data. In image processing tasks …