Executive summary The Stanford–Lancet Commission on the North American Opioid Crisis
was formed in response to soaring opioid-related morbidity and mortality in the USA and …

A 'fourth wave'of high mortality involving methamphetamine and cocaine use has been
gathering force in the USA. Availability and use of illicit fentanyls are still the major drivers of …

Background Sharp exacerbations of the US overdose crisis are linked to polysubstance use
of synthetic compounds. Xylazine is a veterinary tranquilizer, long noted in the street opioid …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Importance US life expectancy has not kept pace with that of other wealthy countries and is
now decreasing. Objective To examine vital statistics and review the history of changes in …

The US mortality rate has gone up three years in a row from 2014 to 2017 (Xu, Murphy,
Kochanek, & Arias, 2016; Murphy, Xu, Kochanek, & Arias, 2018; Kochanek, Murphy, Xu, & …

Opioid-related overdose deaths have increased since 2010 in the US, but information on
trends in opioid use disorder (OUD) prevalence is limited due to unreliable data. Multiplier …

Internalizing conditions of psychopathology include depressive and anxiety disorders; they
most often onset in adolescence, are relatively common, and contribute to significant …

Importance In response to the increase in opioid overdose deaths in the United States, many
states recently have implemented supply-controlling and harm-reduction policy measures …

Importance Firearm fatality rates in the United States have reached a 28-year high.
Describing the evolution of firearm fatality rates across intents, demographics, and …