Non-coding RNA networks in cancer

E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Fasting-mimicking diet and hormone therapy induce breast cancer regression

I Caffa, V Spagnolo, C Vernieri, F Valdemarin… - Nature, 2020 - nature.com
Approximately 75% of all breast cancers express the oestrogen and/or progesterone
receptors. Endocrine therapy is usually effective in these hormone-receptor-positive …

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

C Gong, J Tian, Z Wang, Y Gao, X Wu, X Ding… - Journal of …, 2019 - Springer
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …

The many faces of estrogen signaling

P Vrtačnik, B Ostanek, S Mencej-Bedrač, J Marc - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

Non-coding RNAs in breast cancer: intracellular and intercellular communication

CM Klinge - Non-coding RNA, 2018 - mdpi.com
Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer

R Drula, B Pardini, X Fu… - Proceedings of the …, 2023 - National Acad Sciences
The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are
not yet well understood in malignancies, including in breast cancers (BCs). Given the …

Survival factors regulating ovarian apoptosis--dependence on follicle differentiation

E Markstrom, EC Svensson, R Shao… - …, 2002 - rep.bioscientifica.com
Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Connecting the dots in the associations between diet, obesity, cancer, and microRNAs

K Otsuka, H Nishiyama, D Kuriki, N Kawada… - Seminars in cancer …, 2023 - Elsevier
The prevalence of obesity has reached pandemic levels worldwide, leading to a lower
quality of life and higher health costs. Obesity is a major risk factor for noncommunicable …

The emerging role of miRNA clusters in breast cancer progression

A Kandettu, R Radhakrishnan, S Chakrabarty… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Micro RNAs (miRNAs) are small non-coding RNAs that are essential for regulation of gene
expression of the target genes. Large number of miRNAs are organized into defined units …