Since long before the first approval of gene therapy for retinal disease, ocular gene therapy
has captured the hopes of patients, clinicians, and scientists alike. Indeed, the retina …

Retinitis pigmentosa, defined more properly as cone–rod dystrophy, is a paradigm of
inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in …

Optogenetic therapy has emerged as a promising technique for the treatment of ocular
diseases; however, most optogenetic tools rely on external blue light to activate the …

Optogenetics is an emerging bioengineering technology that has been rapidly developed in
recent years by cross-integrating optics, genetic engineering, electrophysiology, software …

The peripheral nervous system (PNS) of mammals and nervous systems of lower organisms
possess significant regenerative potential. In contrast, although neural plasticity can provide …

Inherited progressive degeneration of photoreceptors such as retinitis pigmentosa (RP) is
the most common cause of blindness leading to severe vision impairment affecting~ 1 in …

To investigate whether the natural progression rate of retinitis pigmentosa (RP) can be
decreased with subtenon Wharton's jelly-derived mesenchymal stem cell (WJ-MSC) …

Maintenance of the visual function is the desired outcome of ophthalmologic therapies. The
shortcomings of the current treatment options, like partial recovery, post-operation failure …

Introduction Ocular gene therapy represents fertile ground for rapid innovation, with ever-
expanding therapeutic strategies, molecular targets, and indications. Areas covered …

This comprehensive review provides a thorough examination of inherited retinal diseases
(IRDs), encompassing their classification, genetic underpinnings, and the promising …