The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue
in human participants. The most frequently used methodologies to evaluate insulin …

Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

Abstract Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes
urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is …

Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of
obesity and T2D is significantly higher in shift workers compared to people working regular …

Objective The objective of this study was to measure changes in glucose, lipid, and
inflammation parameters after transitioning from a baseline diet (BD) to an isocaloric …

Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1
innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed …

Insulin is the master regulator of glucose, lipid, and protein metabolism. Following ingestion
of an oral glucose load or mixed meal, the plasma glucose concentration rises, insulin …

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …