Germline risk of clonal haematopoiesis
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …
somatic mutations that is associated with an increased risk of haematological malignancies …
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …
Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations
One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
JP Dumanski, J Halvardson, H Davies… - Cellular and Molecular …, 2021 - Springer
Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
A Köferle, A Schlattl, A Hörmann, V Thatikonda, A Popa… - Cell reports, 2022 - cell.com
Genetic networks are characterized by extensive buffering. During tumor evolution,
disruption of functional redundancies can create de novo vulnerabilities that are specific to …
disruption of functional redundancies can create de novo vulnerabilities that are specific to …
Super-Planckian emission cannot really be 'thermal'
A heat-powered emitter can sometimes exceed the Planck thermal-emission limit. We clarify
when such super-Planckian emission is possible, arguing that far-field super-Planckian …
when such super-Planckian emission is possible, arguing that far-field super-Planckian …
LDtrait: an online tool for identifying published phenotype associations in linkage disequilibrium
Genome-wide association studies (GWAS) have identified thousands of germline
susceptibility loci associated with risk for cancer as well as a wide range of other traits and …
susceptibility loci associated with risk for cancer as well as a wide range of other traits and …
Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99
J Mattisson, M Danielsson, M Hammond, H Davies… - Scientific Reports, 2021 - nature.com
Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated
with increased risk for morbidity and mortality. The CD99 gene, positioned in the …
with increased risk for morbidity and mortality. The CD99 gene, positioned in the …
Shared and distinct genetic etiologies for different types of clonal hematopoiesis
Abstract Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic
clones—can differ in frequency and cellular fitness by CH type (eg, mutations in driver genes …
clones—can differ in frequency and cellular fitness by CH type (eg, mutations in driver genes …
Loss of Y in leukocytes as a risk factor for critical COVID-19 in men
B Bruhn-Olszewska, H Davies, D Sarkisyan, U Juhas… - Genome Medicine, 2022 - Springer
Background The COVID-19 pandemic, which has a prominent social and economic impact
worldwide, shows a largely unexplained male bias for the severity and mortality of the …
worldwide, shows a largely unexplained male bias for the severity and mortality of the …