Clonal hematopoiesis and inflammation–the perpetual cycle
S Avagyan, LI Zon - Trends in cell biology, 2023 - cell.com
Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …
Determinants of mosaic chromosomal alteration fitness
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
[HTML][HTML] 嵌合染色体变异全基因组关联研究进展
赵禹碹， 宋明钰， 余灿清， 吕筠， 李立明 - 中华流行病学杂志, 2023 - html.rhhz.net
嵌合染色体变异(mCA) 指体细胞突变大规模发生在染色体上使体内有多种核型细胞系的现象,
被视为人类衰老表型之一. mCA 与血液系统癌症, 心脑血管疾病等多种慢性病存在关联, 但mCA …
被视为人类衰老表型之一. mCA 与血液系统癌症, 心脑血管疾病等多种慢性病存在关联, 但mCA …
[HTML][HTML] 中国10 个地区成年人外周血嵌合染色体变异的流行病学分布特征
宋明钰， 赵禹碹， 韩雨廷， 吕筠， 余灿清， 裴培… - 中华流行病学 …, 2023 - html.rhhz.net
目的描述外周血嵌合染色体变异(mCA) 在我国10 个地区30~ 79 岁自然人群的流行病学分布
特征. 方法纳入中国慢性病前瞻性研究(CKB) 10 个项目地区中已有基线数据(人口学特征 …
特征. 方法纳入中国慢性病前瞻性研究(CKB) 10 个项目地区中已有基线数据(人口学特征 …
Effect existence of aging on stutter ratio evaluated via Bayesian inference
S Inokuchi, H Nakanishi, A Takada, K Saito - Forensic Science International …, 2023 - Elsevier
The stochastic behavior of the stutter ratio (SR) in capillary electrophoresis-based DNA
typing is currently described and predicted using statistical models in forensic genetics …
typing is currently described and predicted using statistical models in forensic genetics …
[HTML][HTML] Occurrence of a paroxysmal nocturnal hemoglobinuria clone in an essential thrombocythemia: a link between PIGV and MPL
Figure 1. Follow-up over time of biochemical (LDH, creatininemia, proteinuria [urinary
protein to creatinine ratio, uPCr], soluble urokinase-type plasminogen receptor [uPAR]) and …
protein to creatinine ratio, uPCr], soluble urokinase-type plasminogen receptor [uPAR]) and …
Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis
Introduction Mosaic chromosomal alterations (mCAs) detected in white blood cells represent
a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic …
a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic …
[HTML][HTML] 常染色体嵌合变异的流行病学分布及其影响因素研究进展
宋明钰， 赵禹碹， 韩雨廷， 余灿清， 吕筠， 李立明 - 中华流行病学杂志, 2022 - html.rhhz.net
人类体细胞突变的发生和积累, 又称体细胞嵌合现象. 其中, 嵌合染色体变异(mCA)
对基因组完整性的影响最为显著, 被视为人类衰老的表型之一. 随着全球人口老龄化进程的加速 …
对基因组完整性的影响最为显著, 被视为人类衰老的表型之一. 随着全球人口老龄化进程的加速 …
The role of hematopoietic chromosome Y loss in health and disease
J Mattisson - 2023 - diva-portal.org
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine
1939. 94 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1788-5. Mosaic loss …
1939. 94 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1788-5. Mosaic loss …