Bordetella pertussis-specific antibodies can be detected by enzyme-linked immunosorbent
assays (ELISAs) or multiplex immunoassays. Assays use purified or mixed antigens, and …

Bordetella pertussis is a pathogen-causing whooping cough (pertussis) in humans.
Although vaccination against the disease is effective, the bacterium is still circulating among …

Many vaccines induce protective immunity via antibodies. Systems biology approaches
have been used to determine signatures that can be used to predict vaccine-induced …

Background: Iron deficiency may impair adaptive immunity and is common among African
infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether …

In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and
systemic adverse events that prompted their replacement with acellular pertussis (aP) …

Reported incidence of pertussis in the European Union (EU) and the European Economic
Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection …

BACKGROUND To date, only limited data are available on the mechanisms of protection
against colonization with Bordetella pertussis in humans. METHODS In this study, the …

Background In many countries, the reported pertussis has increased despite high
vaccination coverage. However, accurate determination of the burden of disease is …

Background Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination offers
protection for neonates against clinical pertussis until primary vaccinations, but maternal …

Antibodies are unique among biomarkers in their ability to identify persons with protective
immunity to vaccine-preventable diseases and to measure past exposure to diverse …