Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …

Chromosome instability (CIN) has been repeatedly associated with aging and progeroid
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …

Mosaic loss of Chromosome Y (LOY) is a common acquired structural mutation in the
leukocytes of aging men that is correlated with several age-related diseases, including …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Although germline de novo copy number variants (CNVs) are known causes of autism
spectrum disorder (ASD), the contribution of mosaic (early-developmental) copy number …

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers
for a host of human diseases. Here, to gain a better understanding of mCA rates in …

Background Klinefelter syndrome is a common chromosomal (aneuploidy) disorder
associated with an extra X chromosome in males. Regardless of numerous studies …

Sex chromosomes are typically viewed as having originated from a pair of autosomes, and
differentiated as the sex-limited chromosome (eg Y) has degenerated by losing most genes …

Background Turner's syndrome is associated with either monosomy or a wide spectrum of
structural rearrangements of chromosome X. Despite the interest in studying (somatic) …

Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of individuals
worldwide and can occur relatively early or later in life. It is well known that genetic …