In this brief review, the development of breast cancer is discussed from the vantage of
phenotypic differentiation, similar to what has been considered over the years for leukemias …

Oestrogen receptors (ER) α and β modify the expression of genes involved in cell growth,
proliferation and differentiation through binding to oestrogen response elements (EREs) …

Breast cancer originates in undifferentiated terminal structures of the mammary gland. The
terminal ducts of the Lob 1 of the human female breast, which are the sites of origin of ductal …

Because progesterone exerts its effects mainly via estrogen-dependent progesterone
receptor (PgR), the expression of progesterone's effects may be overshadowed by the …

It has been documented that estrogen receptor (ER) transcription silencing due to
hypermethylation is linked to the tumor progression of breast, uterine and prostate cancers …

Interplay between non-cancerous cells (immune, fibroblasts, mesenchymal stromal cells
(MSC), and endothelial cells (EC)) has been identified as vital in driving tumor progression …

We have compared the DNase I hypersensitivity of the regulatory region of two estrogen-
regulated genes, pS2 and cathepsin D in hormone-dependent and-independent breast …

abstract O-GlcNAcylation is a form of cytoplasmic and nuclear glycosylation that is found on
many diverse proteins of the cell including RNA polymerase II and its associated …

The estrogen hormone (E2) plays an important role in the physiology and pathophysiology
of target tissues. The effects of E2 are conveyed by the estrogen receptors (ER) α and β. The …

Epidermal growth factor (EGF) and estradiol (E2) are important mitogens in breast epithelial
cells, and expression of epidermal growth factor receptor (EGFR) and estrogen receptor …