Background: Estrogen stimulates the proliferation of cells in normal mammary glands and
most estrogen receptor (ER)-positive mammary carcinomas by binding to the ER and …

We previously described frequent overexpression of Sam-pointed domain containing Ets
transcription factor (SPDEF), also known as PDEF, in human breast cancer, and suggested …

Abstract Selective Estrogen Receptor Modulators (SERMs) are a new class of drugsthat bind
to estrogen receptor (ER) and elicit agonistic or antagonistic responses, depending on the …

The xenoestrogen group of endocrine disruptors has the potential to cause reproductive and
developmental effects through stimulation or disruption of sex steroid nuclear receptor …

Prostate-derived Ets factor (PDEF), a member of the Ets family of transcription factors, differs
from other family members in its restricted expression in normal tissues and its unique DNA …

Bone metastasis is the most common metastasis in breast cancer patients. Clinical
observations propose strong association between estrogen receptor (ER)-positive tumors …

In this study, we determined whether ER DNA binding is necessary for estrogen to stimulate
the growth of breast cancer cells. To investigate the requirement of ER DNA binding we …

Oestrogens and antioestrogens modulate the synthesis of transforming growth factor alpha
(TGF-alpha) in breast cancer cells. The purpose of the present report was to examine …

The purpose of this study was to classify selective oestrogen receptor modulators based on
gene expression profiles produced in breast cancer cells expressing either wtERα or mutant …

The incidence of neurodegenerative diseases is higher in postmenopausal women that
young women. In this sense, Alzheimer's and Parkinson's diseases, ischemic brain injury …