Ovarian cancer (OvCA) accounts for one of the leading causes of death from gynecologic
malignancy. Despite progress in therapy improvements in OvCA, most patients develop a …

Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease that resists most
current therapies. A defining characteristic of PDA is an intense fibrotic response that …

Blockade of PD-L1 expression on tumor cells via anti–PD-L1 monoclonal antibody (mAb)
has shown great promise for successful cancer treatment by overcoming T-cell exhaustion; …

This study tested the hypothesis that the expression of CD112 and CD155 (DNAM‐1
ligands) on leukemic blasts induces a decreased expression of the activating receptor …

Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called
NMO) involves AQP4-IgG binding to astrocytes, resulting in astrocyte injury by complement …

The pathogenesis of neuromyelitis optica (NMO) involves targeting of NMO-immunoglobulin
G (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system. Prior work …

Castration-resistant prostate cancer (CRPC) patients have a 14-month median survival,
emphasizing the need for alternative treatments. Previously, we demonstrated that …

Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for
hematological malignancies. However, improvements in CAR T-cell therapies are urgently …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of the non-
homologous end-joining (NHEJ) pathway, is involved in DNA double-strand break repair …

Dendritic cells (DCs) are the major sentinel, antigen-presenting and regulatory components
of the immune system. One of the central DC functions is to rapidly sense and alert host …