[HTML][HTML] Role of copper on mitochondrial function and metabolism
Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
Cuproptosis: Harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
Accessory subunits are integral for assembly and function of human mitochondrial complex I
DA Stroud, EE Surgenor, LE Formosa, B Reljic… - Nature, 2016 - nature.com
Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
[HTML][HTML] Mitochondrial structure and bioenergetics in normal and disease conditions
M Protasoni, M Zeviani - International journal of molecular sciences, 2021 - mdpi.com
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …
involved in various aspects of cellular life, with a primary role in energy production. The …
The genetics and pathology of mitochondrial disease
Mitochondria are double‐membrane‐bound organelles that are present in all nucleated
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …
[HTML][HTML] Getting out what you put in: Copper in mitochondria and its impacts on human disease
Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
Mitochondrial copper in human genetic disorders
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …
diverse physiological processes, including mitochondrial energy generation. Copper enters …
Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes
A Signes, E Fernandez-Vizarra - Essays in biochemistry, 2018 - portlandpress.com
The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …
Mitochondrial cytochrome c oxidase biogenesis: Recent developments
Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …
[HTML][HTML] Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
JX Tang, K Thompson, RW Taylor… - International Journal of …, 2020 - mdpi.com
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …