Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies

KM Koeller, CH Wong - Chemical Reviews, 2000 - ACS Publications
Identifying the functional roles of carbohydrates in biological systems has been an area of
intense study in recent years. Although carbohydrates were once viewed only as inert …

Enzymes in the synthesis of glycoconjugates

RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

Enzyme-catalyzed oligosaccharide synthesis

Y Ichikawa, GC Look, CH Wong - Analytical biochemistry, 1992 - Elsevier
Cell-surface carbohydrates and their conjugates are involved in many types of molecular
recognition. This review describes recent developments in enzyme-catalyzed …

Deoxynojirimycin: synthesis and biological activity

AB Hughes, AJ Rudge - Natural Product Reports, 1994 - pubs.rsc.org
Synthesis of Deoxynojirimycin Analogues N-Derivatized Analogues C-1 Functionalized
Analogues Hydroxyl Substituted Analogues Functionalized Hydroxyl Analogues …

Nucleoside phosphate sugars: syntheses on practical scales for use as reagents in the enzymatic preparation of oligosaccharides and glycoconjugates

JE Heidlas, KW Williams… - Accounts of Chemical …, 1992 - ACS Publications
For many years, the carbohydrates present in living organisms have been identified
primarily with passive roles: compounds used for energy storage, as structural units of cells …

Chemoenzymatic synthesis of ethyl 1-thio-(β-D-galactopyranosyl)-O-β-D-glycopyranosyl disaccharides using the β-galactosidase from Bacillus circulans

G Vic, JJ Hastings, OW Howarth, DHG Crout - Tetrahedron: Asymmetry, 1996 - Elsevier
Different ethyl 1-thio-β-D-disaccharides have been synthesised by transgalactosylation
using the β-galactosidase from Bacillus circulans as biocatalyst. This β-galactosidase shows …

Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide

C Saotome, Y Kanie, O Kanie, CH Wong - Bioorganic & medicinal …, 2000 - Elsevier
Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide -
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Synthesis of, and lack of inhibition of a rhamnosidase by, both enantiomers of deoxyrhamnojirimycin and rhamnolactam: β-mannosidase inhibition by δ-lactams

AJ Fairbanks, NC Carpenter, GWJ Fleet, NG Ramsden… - Tetrahedron, 1992 - Elsevier
Synthesis of both enantiomers of deoxyrhamnojirimycin and rhamnonolactam from D-and L-
gulonolactones are described. The effects as inhibitors of the enantiomeric …

Perspectives in total synthesis: a personal account

KC Nicolaou - Tetrahedron, 2003 - Elsevier
Endeavors in total synthesis provide unique opportunities to discover and invent new
strategies and tools for constructing organic molecules and they shape the art, science, and …

Sugar derivatives having sulfur in the ring

JG Fernändez-Bolaños, NAL Al-Masoudi, I Maya - 2001 - Elsevier
Publisher Summary This chapter discusses the chemistry of sugar derivatives containing
sulfur in the ring, including mono-and oligo-saccharides, 4'-thionucleosides, and 3'-deoxy-3' …