Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC
Y Li, Y Zhang, F Qiu, Z Qiu - Electrophoresis, 2011 - Wiley Online Library
In the present research, we aimed to screen for non‐small cell lung cancer (NSCLC)‐related
proteins in urinary exosomes by comparing urinary exosomes proteome of normal controls …
proteins in urinary exosomes by comparing urinary exosomes proteome of normal controls …
PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy
Purpose: Activating extrinsic apoptotic pathways targeting death receptors (DR) using
agonistic antibodies or TNF-related apoptosis-inducing ligand (TRAIL) is promising for …
agonistic antibodies or TNF-related apoptosis-inducing ligand (TRAIL) is promising for …
FLIP: molecular switch between apoptosis and necroptosis
JJ Gong, SA Kumar, G Graham… - Molecular …, 2014 - Wiley Online Library
Cancerous growth is one of the most difficult diseases to target as there is no one clear
cause, and targeting only one pathway does not generally produce quantifiable …
cause, and targeting only one pathway does not generally produce quantifiable …
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells
K Bijangi-Vishehsaraei, MR Saadatzadeh… - Molecular and cellular …, 2010 - Springer
Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
major resistance factor for the tumor necrosis factor-related apoptosis-inducing ligand TRAIL …
major resistance factor for the tumor necrosis factor-related apoptosis-inducing ligand TRAIL …
Pentamerisation of a scFv directed against TRAIL receptor 2 increases its antitumour efficacy
W Wang, W He, L Wang, G Zhang… - Immunology and Cell …, 2013 - Wiley Online Library
Single‐chain variable fragments (scFvs) have been considered as promising therapeutic
drugs. However, their low affinity and rapid clearance from the blood have limited their wider …
drugs. However, their low affinity and rapid clearance from the blood have limited their wider …
[HTML][HTML] Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death
P Zhang, Y Zheng, J Shi, Y Zhang, S Liu, Y Liu… - Journal of biological …, 2010 - ASBMB
Tumor necrosis factor-related apoptosis-inducing ligand receptors death receptor (DR) 4
and DR5 are potential targets for antibody-based cancer therapy. Activation of the …
and DR5 are potential targets for antibody-based cancer therapy. Activation of the …
Immunotherapeutic molecules and uses
The invention provides molecule comprising:(i) a targeting moiety capable of directly or
indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell …
indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell …
c-FLIP (L) 在乳腺癌中表达的意义及对凋亡的调节
臧凤琳， 魏熙胤， 孙蕾娜， 孙保存 - 中国肿瘤临床, 2010 - cjco.cn
目的: 检测乳腺浸润性导管癌组织中c-FLIP (L) 蛋白的表达, 探讨c-FLIP (L)
在乳腺癌中的临床病理意义, 以及对乳腺癌细胞凋亡, 增殖的影响. 方法: 收集116 …
在乳腺癌中的临床病理意义, 以及对乳腺癌细胞凋亡, 增殖的影响. 方法: 收集116 …
[HTML][HTML] β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors
C You, S Zhang, Y Sun, S Zhang… - International …, 2018 - spandidos-publications.com
Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) exhibits antitumor activity in
various types of tumor cell and tumor‑bearing animals. However, acquired TRAIL resistance …
various types of tumor cell and tumor‑bearing animals. However, acquired TRAIL resistance …
[HTML][HTML] Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain
HJ Huang, M Zhang - International Journal of Clinical and …, 2014 - ncbi.nlm.nih.gov
Abstract Phosphatidylinositol 3-kinase (PI3K) signaling plays a pivotal role in intracellular
signal transduction pathways involved in chronic pain states. PI3K is implicated in …
signal transduction pathways involved in chronic pain states. PI3K is implicated in …