The Pichia pastoris expression system is being used successfully for the production of
various recombinant heterologous proteins. Recent developments with respect to the Pichia …

Each subcellular compartment in yeast offers a unique physiochemical environment and
metabolite, enzyme, and cofactor composition. While yeast metabolic engineering has …

X-ray crystallography is an established method for studying the structure of proteins and
other macromolecules. As the importance of proteins grows, researchers in many fields have …

Yeasts are widely used in production of recombinant proteins of medical or industrial
interest. For each individual product, the most suitable expression system has to be …

The methylotrophic yeast Pichia pastoris is widely used for the production of proteins and as
a model organism for studying peroxisomal biogenesis and methanol assimilation. P …

Yeast and fungal protein expression systems are used for the production of many industrially
relevant enzymes, and are widely used by the research community to produce proteins that …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

As the fastest growing class of therapeutic proteins, monoclonal antibodies (mAbs)
represent a major potential drug class. Human antibodies are glycosylated in their native …

Almost all of the 200 or so approved biopharmaceuticals have been produced in one of
three host systems: the bacterium Escherichia coli, yeasts (Saccharomyces cerevisiae …

Yeast is a widely used recombinant protein expression system. We expanded its utility by
engineering the yeast Pichia pastoris to secrete human glycoproteins with fully complex …