Identification of a novel T cell-related signature to predict prognosis in colorectal cancer via integrating single-cell and bulk RNA sequencing

W Zhang, X Zhu, R Wen, J Wu, L Zhou, H Fan, Y Li… - 2024 - researchsquare.com
Background: T cells, the key mediators of tumor destruction, have a considerable impact on
tumor prognosis. However, the clinical significance of T cell-associated biomarkers in …

Toward Best Practice in Identifying Subtle Differential Expression with RNA-seq: A Real-World Multi-Center Benchmarking Study Using Quartet and MAQC Reference …

D Wang, Y Liu, Y Zhang, Q Chen, Y Han, W Hou, C Liu… - bioRxiv, 2023 - biorxiv.org
Translating RNA-seq into clinical diagnostics requires ensuring the reliability of detecting
clinically relevant subtle differential expressions, such as those between different disease …

Machine learning developed a macrophage signature for predicting prognosis, immune infiltration and immunotherapy features in head and neck squamous cell …

Y Wang, YK Mou, WC Liu, HR Wang, XY Song, T Yang… - 2024 - researchsquare.com
Macrophages played an important role in the progression and treatment of cancer.
Nevertheless, there is a limited amount of research that has comprehensively elucidated the …

Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma

Z Yao, L Lu, Q Xu, S Hua, H Wang… - Clinical, Cosmetic and …, 2024 - dovepress.com
Background: High levels of UV exposure are a significant factor that can trigger the onset
and progression of SKCM. Moreover, this exposure is closely linked to the malignancy of the …

SLC8A1, a novel prognostic biomarker and immunotherapy target in RSA and UCEC based on scRNA-seq and pan-cancer analysis

J Chu, X Qin, X Xu - 2023 - researchsquare.com
Purpose As the field of gynecological immunology increasingly focuses on reproduction, the
importance of recurrent spontaneous abortion (RSA) is growing. The complex mechanisms …