We describe the collection of cohorts together with the analysis plan for an update of the
fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource …

The epidemiological connection between diabetes, obesity, and dementia represents an
important public health challenge but also an opportunity to further understand these …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Risk stratification is critical for the early identification of high-risk individuals and disease
prevention. Here we explored the potential of nuclear magnetic resonance (NMR) …

Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …

Importance Previous studies have indicated that gut microbiome may be associated with
development of type 2 diabetes. However, these studies are limited by small sample size …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-
START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to …

Traditional neuroimage analysis pipelines involve computationally intensive, time-
consuming optimization steps, and thus, do not scale well to large cohort studies with …

COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The
viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) …