The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo
generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate …

Myocardial infarction (MI) is one of the most common cardiac emergencies with high
morbidity and is a leading cause of death worldwide. Since MI could develop into a life …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de
novo arginine production. The latter may be linked to the availability of citrulline, which is the …

Throughout the human gastrointestinal tract a variety of reactive nitrogen oxides are
continuously formed as a result of a complex interplay between the host, commensal …