Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Background Cancer incidence is higher in men than in women at most shared anatomic
sites for currently unknown reasons. The authors quantified the extent to which behaviors …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Historically women were frequently excluded from clinical trials and drug usage to protect
unborn babies from potential harm. As a consequence, the impact of sex and gender on …

Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …

Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated
with increased risk for morbidity and mortality. The CD99 gene, positioned in the …

Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men.
However, LoY is highly increased in tumor tissue and correlates with an overall worse …