Recent advances in our knowledge of arsenic carcinogenesis include the development of
rat or mouse models for all human organs in which inorganic arsenic is known to cause …

The interaction of sunlight with drug medication leads to photosensitivity responses in
susceptible patients, and has the potential to increase the incidence of skin cancer. Adverse …

The naturally occurring polyamines putrescine, spermidine, and spermine are involved in
signal transduction. This has been demonstrated by using inhibitors for polyamine …

There has been a paucity of evidence showing that 12-O-tetradecanoylphorbol-13-acetate
(TPA), a potent tumor promoter, causes DNA damage in vivo. We show that oxidized DNA …

Abstract Development of nervous tissue is controlled, in part, by the ornithine decarboxylase
(ODC)/polyamine system. Each brain region possesses a unique ontogenetic pattern for …

Background: Experimental studies have indicated dietary fish oil as a protective agent in
colon carcinogenesis. Prostaglandins have been suggested to be involved in this process …

The effect of the green tea polyphenol-(−) epigallocatechin-3-gallate (EGCG) was tested in
cultures of normal and transformed NIH-pATM ras fibroblasts. In this system transformation …

The polyamines spermine, spermidine, and putrescine are small organic molecules one or
more of which are present in all living organisms. Many natural products contain polyamine …

Pyrrolizidine alkaloids unsaturated in the 1, 2 position are hepatotoxins. Certain of them,
such as monocrotaline, are also pneumotoxins, producing pulmonary arterial hypertension …

Direct exposure of small intestinal mucosal cells to luminal polyamines stimulates
proliferation. This study tests the hypothesis that the protooncogenes c-fos, c-myc, c-jun, and …