Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …

The use of viral vectors for inner ear gene therapy is receiving increased attention for
treatment of genetic hearing disorders. Most animal studies to date have injected viral …

Dizziness and hearing loss are among the most common disabilities. Many forms of
hereditary balance and hearing disorders are caused by abnormal development of …

There is growing attention and effort focused on treating the root cause of sensorineural
hearing loss rather than managing associated secondary characteristic features. With recent …

Gene therapy is a promising treatment modality that is being explored for several inherited
disorders. Multiple human gene therapy clinical trials are currently ongoing, but few are …

Background Noise-induced hearing loss represents a commonly diagnosed type of hearing
disability, severely impacting the quality of life of individuals. The current work is aimed at …

Gene therapy for genetic deafness is a promising approach by which to prevent hearing loss
or to restore hearing after loss has occurred. Although a variety of direct approaches to …

Local delivery of therapeutic drugs into the inner ear is a promising therapy for inner ear
diseases. Injection through semicircular canals (canalostomy) has been shown to be a …

Inner ear gene therapy offers great promise as a potential treatment for hearing loss and
dizziness. One of the critical determinants of the success of inner ear gene therapy is to find …