Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory

SF Brenière, E Waleckx, C Barnabé - PLoS neglected tropical …, 2016 - journals.plos.org
Trypanosoma cruzi, the causative agent of Chagas disease, presents wide genetic diversity.
Currently, six discrete typing units (DTUs), named TcI to TcVI, and a seventh one called …

Discrete typing units of Trypanosoma cruzi: Geographical and biological distribution in the Americas

N Velásquez-Ortiz, G Herrera, C Hernández, M Muñoz… - Scientific data, 2022 - nature.com
Chagas disease caused by Trypanosoma cruzi is a public health issue in Latin America.
This highly diverse parasite is divided into at least seven discrete typing units (DTUs) TcI …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …

CB Moraes, MA Giardini, H Kim, CH Franco… - Scientific reports, 2014 - nature.com
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …

[HTML][HTML] Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches

BA Noya, Z Díaz-Bello, C Colmenares… - Memórias do Instituto …, 2015 - SciELO Brasil
Orally transmitted Chagas disease has become a matter of concern due to outbreaks
reported in four Latin American countries. Although several mechanisms for orally …

Congenital Chagas disease: current diagnostics, limitations and future perspectives

LA Messenger, C Bern - Current opinion in infectious diseases, 2018 - journals.lww.com
Congenital Chagas disease remains an important contributor to the global disease burden
because of T. cruzi. PCR and related molecular techniques represent the most sensitive …

The ecology and natural history of wild Triatominae in the Americas

F Abad-Franch, R Gurgel-Gonçalves - Triatominae-The Biology of Chagas …, 2021 - Springer
Triatomine bugs, the vectors of Chagas disease, feed primarily on vertebrate blood and live
in close association with their hosts. Here we provide an updated synthesis of current …

Landscape ecology of Trypanosoma cruzi in the southern Yucatan Peninsula

SA López-Cancino, E Tun-Ku, HK De la Cruz-Felix… - Acta tropica, 2015 - Elsevier
Landscape interactions of Trypanosoma cruzi (Tc) with Triatoma dimidiata (Td) depend on
the presence and relative abundance of mammal hosts. This study analyzed a landscape …