[HTML][HTML] Evidence of sex differences in cellular senescence
M Ng, LN Hazrati - Neurobiology of Aging, 2022 - Elsevier
Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …
cancer, and more. For each of these, men and women display distinct differences in disease …
Mosaicism and clinical genetics
NB Spinner, LK Conlin - … Journal of Medical Genetics Part C …, 2014 - Wiley Online Library
With the introduction of increasingly sensitive technologies for mutation detection such as
chromosomal microarrays and next‐generation sequencing, the importance of mosaicism …
chromosomal microarrays and next‐generation sequencing, the importance of mosaicism …
Mosaic loss of chromosome Y is associated with common variation near TCL1A
Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs
during aging, particularly in smokers. We investigated whether mLOY was associated with …
during aging, particularly in smokers. We investigated whether mLOY was associated with …
[HTML][HTML] Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
[HTML][HTML] Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP
microarray intensity data of 38,303 women from cancer genome-wide association studies …
microarray intensity data of 38,303 women from cancer genome-wide association studies …
[HTML][HTML] Characterization of large structural genetic mosaicism in human autosomes
Analyses of genome-wide association study (GWAS) data have revealed that detectable
genetic mosaicism involving large (> 2 Mb) structural autosomal alterations occurs in a …
genetic mosaicism involving large (> 2 Mb) structural autosomal alterations occurs in a …
Mosaic Y loss is moderately associated with solid tumor risk
Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event in
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
[HTML][HTML] Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations
EM Kwon, JP Connelly, NF Hansen… - Proceedings of the …, 2017 - National Acad Sciences
Genome integrity of induced pluripotent stem cells (iPSCs) has been extensively studied in
recent years, but it is still unclear whether iPSCs contain more genomic variations than …
recent years, but it is still unclear whether iPSCs contain more genomic variations than …
[HTML][HTML] Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in …
Background Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …