[HTML][HTML] Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Detecting axonal injury in individual patients after traumatic brain injury

AE Jolly, M Bălăeţ, A Azor, D Friedland, S Sandrone… - Brain, 2021 - academic.oup.com
Poor outcomes after traumatic brain injury (TBI) are common yet remain difficult to predict.
Diffuse axonal injury is important for outcomes, but its assessment remains limited in the …

Permeability of the blood–brain barrier after traumatic brain injury: radiological considerations

M Amoo, PJ O'Halloran, J Henry… - Journal of …, 2022 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of death and disability, especially in young
persons, and constitutes a major socioeconomic burden worldwide. It is regarded as the …

From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury

CK Donat, M Yanez Lopez, M Sastre, N Baxan… - Brain, 2021 - academic.oup.com
The relationship between biomechanical forces and neuropathology is key to understanding
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …

Effect of transcranial low-level light therapy vs sham therapy among patients with moderate traumatic brain injury: a randomized clinical trial

MGF Longo, CO Tan, S Chan, J Welt… - JAMA network …, 2020 - jamanetwork.com
Importance Preclinical studies have shown that transcranial near-infrared low-level light
therapy (LLLT) administered after traumatic brain injury (TBI) confers a neuroprotective …

Disruption of the ascending arousal network in acute traumatic disorders of consciousness

SB Snider, YG Bodien, M Bianciardi, EN Brown, O Wu… - Neurology, 2019 - AAN Enterprises
Objective To determine whether ascending arousal network (AAn) connectivity is reduced in
patients presenting with traumatic coma. Methods We performed high-angular-resolution …

Repetitive model of mild traumatic brain injury produces cortical abnormalities detectable by magnetic resonance diffusion imaging, histopathology, and behavior

F Yu, DK Shukla, RC Armstrong, CM Marion… - Journal of …, 2017 - liebertpub.com
Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute
through chronic effects of head injuries, particularly after repetitive impacts. To better detect …

White matter changes related to subconcussive impact frequency during a single season of high school football

SJ Kuzminski, MD Clark, MA Fraser… - American Journal …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high
school football player to subconcussive impacts during a single season is unknown. The …

The role of diffusion tensor imaging in characterizing injury patterns on athletes with concussion and subconcussive injury: a systematic review

M Tayebi, SJ Holdsworth, AA Champagne, DJ Cook… - Brain injury, 2021 - Taylor & Francis
Traumatic brain injury (TBI) is a major public health problem. The majority of TBIs are in the
form of mild TBI (also known as concussion) with sports-related concussion (SRC) receiving …

Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury

DJ Robles, A Dharani, KA Rostowsky, NN Chaudhari… - GeroScience, 2022 - Springer
Little is known on how mild traumatic brain injury affects white matter based on age at injury,
sex, cerebral microbleeds, and time since injury. Here, we study the fractional anisotropy of …