Aptamer-grafted, cell membrane-coated dendrimer loaded with doxorubicin as a targeted nanosystem against epithelial cellular adhesion molecule (EpCAM) for triple …

A Sheikh, MAS Abourehab, AS Tulbah… - Journal of Drug Delivery …, 2023 - Elsevier
The major issue associated with chemotherapeutics is the non-specific distribution,
extended range of toxicity, and low intratumoral accumulation. Targeted therapy using …

[HTML][HTML] Anti-cancer drug solubility development within a green solvent: Design of novel and robust mathematical models based on artificial intelligence

B Huwaimel, A Alobaida - Molecules, 2022 - mdpi.com
Nowadays, supercritical CO2 (SC-CO2) is known as a promising alternative for
challengeable organic solvents in the pharmaceutical industry. The mathematical prediction …

[HTML][HTML] Prevention and eradication of biofilm by dendrimers: A possibility still little explored

S Alfei, D Caviglia - Pharmaceutics, 2022 - mdpi.com
Multidrug resistance (MDR) among pathogens and the associated infections represent an
escalating global public health problem that translates into raised mortality and healthcare …

[HTML][HTML] Eradication of Candida albicans Biofilm Viability: In vitro combination therapy of cationic carbosilane dendrons derived from 4-phenylbutyric Acid with AgNO3 …

N Gómez-Casanova, T Lozano-Cruz, J Soliveri… - Journal of Fungi, 2021 - mdpi.com
Candida albicans is a human pathogen of significant clinical relevance. This pathogen is
resistant to different drugs, and most clinical antifungals are not effective against the …

[HTML][HTML] Polyamidoamine-stabilized and hyaluronic acid-functionalized gold nanoparticles for cancer therapy

MAA Maki, MS Teng, KF Tan, PV Kumar - OpenNano, 2023 - Elsevier
Gold nanoparticles (AuNPs) are versatile nanomaterials that can be used as drug delivery
systems and photothermal agents for cancer therapy. In this study, we developed a novel …

Aptamer-functionalized dendrimers for targeted cancer therapy

A Sheikh, H Kaur, MAS Abourehab, MS Alam… - … Nanocarriers for Cancer …, 2023 - Elsevier
The concept of cancer-based therapy relies upon the improvement of efficacy with a
reduction in toxicity. The chemotherapeutic agents have shown indiscriminate toxic …

[PDF][PDF] Dendrimers as modifiers of inorganic nanoparticles for therapeutic delivery in cancer. Pharmaceutics. 2023; 15: 398

M Zenze, A Daniels, M Singh - 2023 - researchgate.net
The formulation of nanoscale systems with well-defined sizes and shapes is of great interest
in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are …

[HTML][HTML] Anti-biofilm, drug delivery and cytotoxicity properties of dendrimers

CK Ezeh, MEU Dibua - ADMET and DMPK, 2024 - hrcak.srce.hr
Background and purpose Treatments using antimicrobial agents have faced many
difficulties as a result of biofilm formation by pathogenic microorganisms. The biofilm matrix …

Dendrimers: an effective drug delivery and therapeutic approach

B Gorain, H Choudhury, AB Nair… - Design and Applications …, 2023 - Elsevier
The novel hyperbranched, three-dimensional tree-like globular dendritic structures are
gaining popularity in the pharmaceutical field because of their attractive characteristics. The …

Futuristic aspect of nanocarriers on targeted delivery for dementia

S Kumari, JS Bhardwaj, SS Kharavtekar… - … -Based Approaches for …, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Analysis
conducted over the past 20 years has shown that macromolecules accumulating in the brain …