Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells

R Liu, JP Jin - Gene, 2016 - Elsevier
Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and
many types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN 3 …

Smooth muscle signalling pathways in health and disease

HR Kim, S Appel, S Vetterkind… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Mechanisms that regulate LC20 phosphorylation‐Regulation of myosin
phosphatase‐CaMKII• Mechanisms that regulate the access of myosin to actin‐Caldesmon …

Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation

MM Hossain, DY Hwang, QQ Huang… - American Journal of …, 2003 - journals.physiology.org
h2-Calponin is found in both smooth muscle and nonmuscle cells, and its function remains
to be established. Western blots with specific monoclonal antibodies detected significant …

[HTML][HTML] h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton

MM Hossain, JF Crish, RL Eckert, JJC Lin… - Journal of Biological …, 2005 - ASBMB
Calponin is an extensively studied actin-binding protein, but its function is not well
understood. Among three isoforms of calponin, h2-calponin is found in both smooth muscle …

Conformational Modulation of Troponin T by Configuration of the NH2-Terminal Variable Region and Functional Effects

J Wang, JP Jin - Biochemistry, 1998 - ACS Publications
Troponin T (TnT) is an essential element in the thin filament-based regulatory system of
striated muscle. Alternative mRNA splicing generates multiple TnT isoforms with primary …

[HTML][HTML] Role of H2-calponin in regulating macrophage motility and phagocytosis

QQ Huang, MM Hossain, K Wu, K Parai… - Journal of Biological …, 2008 - ASBMB
The actin cytoskeleton plays a major role in cell motility that is essential for the function of
phagocytes. Calponin is an actin-associated regulatory protein. Here we report the finding of …

[HTML][HTML] Unzipping the role of myosin light chain phosphatase in smooth muscle cell relaxation

QQ Huang, SA Fisher, FV Brozovich - Journal of Biological Chemistry, 2004 - ASBMB
Recently, it has been hypothesized that myosin light chain (MLC) phosphatase is activated
by cGMP-dependent protein kinase (PKG) via a leucine zipper-leucine zipper (LZ-LZ) …

[HTML][HTML] Contractile properties and proteins of smooth muscles of a calponin knockout mouse

JD Matthew, AS Khromov, MJ McDuffie… - The Journal of …, 2000 - ncbi.nlm.nih.gov
The role of h1-calponin in regulating the contractile properties of smooth muscle was
investigated in bladder and vas deferens of mice carrying a targeted mutation in both alleles …

[HTML][HTML] Evolution and function of calponin and transgelin

TB Hsieh, JP Jin - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Calponin and transgelin (originally named SM22) are homologous cytoskeleton proteins
that regulate actin-activated myosin motor functions in smooth muscle contraction and non …

Mechanoregulation of SM22α/transgelin

R Liu, MM Hossain, X Chen, JP Jin - Biochemistry, 2017 - ACS Publications
SM22α, also named transgelin, is an actin filament-associated protein in smooth muscle and
fibroblasts. Three decades after its discovery, the biological function of SM22α remains …