Correlates of immunity to Group A Streptococcus: a pathway to vaccine development
H Frost, JL Excler, S Sriskandan, A Fulurija - npj Vaccines, 2023 - nature.com
Understanding immunity in humans to Group A Streptococcus (Strep A) is critical for the
development of successful vaccines to prevent the morbidity and mortality attributed to Strep …
development of successful vaccines to prevent the morbidity and mortality attributed to Strep …
Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections
AL Whitcombe, R McGregor, J Bennett… - The Journal of …, 2022 - academic.oup.com
Abstract Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin
infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) …
infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) …
Development and Characterisation of a Four-Plex Assay to Measure Streptococcus pyogenes Antigen-Specific IgG in Human Sera
The measurement of antibodies to vaccine antigens is crucial for research towards a safe
and effective vaccine for Streptococcus pyogenes (Strep A). We describe the establishment …
and effective vaccine for Streptococcus pyogenes (Strep A). We describe the establishment …
[HTML][HTML] Development and characterization of a hemolysis inhibition assay to determine functionality of anti-Streptolysin O antibodies in human sera
M Carducci, A Whitcombe, L Rovetini, L Massai… - Journal of …, 2024 - Elsevier
The high burden of disease and the long-lasting sequelae following Streptococcus
pyogenes (Strep A) infections make the development of an effective vaccine a global health …
pyogenes (Strep A) infections make the development of an effective vaccine a global health …
[HTML][HTML] Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia (SpyCATS): protocol for a …
EP Armitage, AJ Keeley… - Wellcome Open …, 2023 - ncbi.nlm.nih.gov
Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within
households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study …
households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study …
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.
J Osowicki, HR Frost, KI Azzopardi, AL Whitcombe… - bioRxiv, 2024 - biorxiv.org
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded
vaccine development. To address these gaps and evaluate vaccine candidates, we …
vaccine development. To address these gaps and evaluate vaccine candidates, we …
Novel multiplex immunoassays for two important infectious diseases in Aotearoa New Zealand
AL Whitcombe - 2022 - researchspace.auckland.ac.nz
Acute rheumatic fever (ARF), caused by Group A Streptococcus (GAS), as well as COVID-
19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are both …
19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are both …