[HTML][HTML] Histone recycling by FACT and Spt6 during transcription prevents the scrambling of histone modifications
C Jeronimo, C Poitras, F Robert - Cell reports, 2019 - cell.com
Genomic DNA is framed by additional layers of information, referred to as the epigenome.
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …
Whole‐genome sequencing reveals new Alzheimer's disease–associated rare variants in loci related to synaptic function and neuronal development
D Prokopenko, SL Morgan, K Mullin… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Genome‐wide association studies have led to numerous genetic loci
associated with Alzheimer's disease (AD). Whole‐genome sequencing (WGS) now permits …
associated with Alzheimer's disease (AD). Whole‐genome sequencing (WGS) now permits …
[HTML][HTML] Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice–identification of selective stimuli for insulin-like peptide-5 and glucagon-like …
Abstract Objective Enteroendocrine cells (EECs) of the large intestine, found scattered in the
epithelial layer, are known to express different hormones, with at least partial co-expression …
epithelial layer, are known to express different hormones, with at least partial co-expression …
[HTML][HTML] Transcriptional effects of copy number alterations in a large set of human cancers
A Bhattacharya, RD Bense… - Nature …, 2020 - nature.com
Copy number alterations (CNAs) can promote tumor progression by altering gene
expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not …
expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not …
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
MG Oser, AH Sabet, W Gao… - Genes & …, 2019 - genesdev.cshlp.org
More than 90% of small cell lung cancers (SCLCs) harbor loss-of-function mutations in the
tumor suppressor gene RB1. The canonical function of the RB1 gene product, pRB, is to …
tumor suppressor gene RB1. The canonical function of the RB1 gene product, pRB, is to …
[HTML][HTML] MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2018 - academic.oup.com
Abstract The 2018 Nucleic Acids Research Database Issue contains 181 papers spanning
molecular biology. Among them, 82 are new and 84 are updates describing resources that …
molecular biology. Among them, 82 are new and 84 are updates describing resources that …
Whole-genome alignment and comparative annotation
Rapidly improving sequencing technology coupled with computational developments in
sequence assembly are making reference-quality genome assembly economical. Hundreds …
sequence assembly are making reference-quality genome assembly economical. Hundreds …
Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease
Genome-wide association studies have identified many loci associated with Alzheimer's
dementia. However, these variants only explain part of the heritability of Alzheimer's disease …
dementia. However, these variants only explain part of the heritability of Alzheimer's disease …
[HTML][HTML] Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies
The evolution of sexual dimorphism is constrained by a shared genome, leading to 'sexual
antagonism', in which different alleles at given loci are favoured by selection in males and …
antagonism', in which different alleles at given loci are favoured by selection in males and …