Physcion and physcion 8-O-β-D-glucopyranoside: natural anthraquinones with potential anticancer activities

M Adnan, A Rasul, G Hussain, MA Shah… - Current Drug …, 2021 - ingentaconnect.com
Nature has provided prodigious reservoirs of pharmacologically active compounds for drug
development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are …

Development of potential antitumor agents from the scaffolds of plant-derived terpenoid lactones

Y Ren, AD Kinghorn - Journal of medicinal chemistry, 2020 - ACS Publications
Naturally occurring terpenoid lactones and their synthetic derivatives have attracted
increasing interest for their promising antitumor activity and potential utilization in the …

Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents

M Mioc, A Mioc, A Prodea, A Milan… - International Journal of …, 2022 - mdpi.com
Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and
selective anticancer agents whose underlying mechanisms of action have been widely …

Conjugation of triterpenic acids of ursane and oleanane types with mitochondria-targeting cation F16 synergistically enhanced their cytotoxicity against tumor cells

MV Dubinin, DA Nedopekina, AI Ilzorkina… - Membranes, 2023 - mdpi.com
The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic,
maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung …

[PDF][PDF] Phytochemical profile, antioxidant, cytotoxic and anti-inflammatory activities of stem bark extract and fractions of Ailanthus excelsa Roxb.: In vitro, in vivo and in …

PR Sapkal, AU Tatiya, SD Firke, VK Redasani… - Heliyon, 2023 - cell.com
This study aimed to assess the phytochemical composition, in vitro antioxidant, cytotoxicity,
and in vivo anti-inflammatory activities of the methanolic extract of Ailanthus excelsa …

Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills

V Consoli, AN Fallica, V Sorrenti, V Pittala… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The multifactorial nature of the mechanisms implicated in cancer development
still represents a major issue for the success of established antitumor therapies. The …

The potential of secondary metabolites from plants as drugs or leads against trypanosoma cruzi-an update from 2012 to 2021

H Barbosa, F Thevenard… - Current Topics in …, 2023 - ingentaconnect.com
Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …

Multiple myeloma inhibitory activity of plant natural products

K Jöhrer, SS Ҫiҫek - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma is the second most common hematological cancer and
is still incurable. Although enhanced understanding of the disease background and the …

Antiplasmodial compounds from Urera gravenreuthii (Urticaceae), their structure-activity relationship and chemotaxonomic significance

GM Happi, LC Dzouemo, GPM Kemayou… - South African Journal of …, 2023 - Elsevier
Abstract The liana Urera gravenreuthii Engl. is an endemic plant to Cameroon which was
not yet been chemically and pharmacologically investigated so far despite its uses for …

Novel A-ring chalcone derivatives of oleanolic and ursolic amides with anti-proliferative effect mediated through ROS-triggered apoptosis

E Khusnutdinova, A Petrova, Z Zileeva… - International journal of …, 2021 - mdpi.com
A series of A-ring modified oleanolic and ursolic acid derivatives including C28 amides (3-
oxo-C2-nicotinoylidene/furfurylidene, 3β-hydroxy-C2-nicotinoylidene, 3β-nicotinoyloxy-, 2 …