Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

This review discusses recent advances in our understanding of the role filopodia and
filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in …

Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the
leading edge, mature focal adhesions and spread morphologies. These observations result …

The topographic features of an implant, which mechanically regulate cell behaviors and
functions, are critical for the clinical success in tissue regeneration. How cells sense and …

The electrospinning technique for nanofiber production has opened new and interesting
opportunities for tissue regeneration and treatment, because they allow biomimetic supports …

Women with dense breasts have an increased lifetime risk of malignancy that has been
attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

Tailoring the surface of biomaterial scaffolds has been a key strategy to modulate the
cellular interactions that are helpful for tissue healing process. In particular, nanotopological …

Fabricating polycaprolactone (PCL) composite can be a facile approach to improve
wettability, mechanical properties and cellular compatibility of PCL-based scaffolds. In this …

Circulating rare cells in the blood are of great significance for both materials research and
clinical applications. For example, circulating tumor cells (CTCs) have been demonstrated …