Recently, one of the authors (KI) and other investigators reported that myosin light chain
(MLC) of smooth muscle (gizzard, arterial and tracheal) was diphosphorylated by myosin …

We prepared anti-platelet 20-kDa myosin light chain (MLC-20) antibody and demonstrated
diphosphorylation of MLC-20 in platelets ex vivo in the initial phase of activation by …

The actin-myosin interaction of vascular smooth muscle cells (VSMCs) is regulated by
myosin light chain kinase (MLCK), which is a fusion protein of the central catalytic domain …

BACKGROUND: Beraprost sodium, an orally active prostacyclin analogue, has proved to be
beneficial for the patients with primary pulmonary hypertension and obstructive peripheral …

An antibody with specificity for the 20 kDa myosin light chain of smooth muscle
phosphorylated by myosin light chain kinase was developed. The antibody was raised …

The protein kinase inhibitor Staurosporine was found to be a potent relaxant of rabbit aortic
strips contracted by various agonists. This relaxing effect was slow, long-lasting and in a non …

Objectives—Acyclic retinoid (ACR) is a synthetic retinoid with a high safety profile that has
been pursued with high expectations for therapeutic use in prevention (recurrence) and …

The metabolism of endogenous and exogenous diacylglycerol (DG) was studied in SM-3
cells derived from rabbit aortic smooth muscle to determine the biochemical step (s) …

The use of autologous saphenous veins for reconstruction of occluded, atherosclerotic
peripheral and coronary arteries is a surgical procedure widely used to relieve the …

Abstract Prostaglandin (PG) F 2α (30 μM) stimulated both monophosphorylation and
diphosphorylation of myosin light chain (MLC) in a smooth muscle cell line (SM-3). The …