Among people with chronic pain, insomnia is highly prevalent, closely related to the
mechanism of central sensitization, characterized by low-grade neuroinflammation, and …

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain.
Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated …

The pathophysiological function of the G-protein coupled melatonin MT 1 and MT 2
receptors has not yet been well-clarified. Recent advancements using selective MT 1/MT 2 …

The involvement of melatonin in mammalian brain pathophysiology has received growing
interest, but information about the anatomical distribution of its two G‐protein‐coupled …

Diabetes and diabetic complications are considered as leading causes of both morbidity
and mortality in the world. Unfortunately, routine medical treatments used for affected …

Introduction: The mechanism of sensitization of the central nervous system partly explains
the chronic pain experience in many patients, but the etiological mechanisms of this central …

Cancer pain remains a significant clinical problem worldwide. Causes of cancer pain are
multifactorial and complex and are likely to vary with an array of tumor-related and host …

Melatonin is a neurohormone secreted by epiphysis and extrapineal structures. It performs
several functions including chronobiotic, antioxidant, oncostatic, immune modulating …

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

Endometriosis is defined as the development of endometrial glands and stroma outside the
uterine cavity. Pathophysiology of this disease includes abnormal hormone profiles, cell …