[HTML][HTML] The changing therapeutic landscape of metastatic renal cancer

JC Angulo, O Shapiro - Cancers, 2019 - mdpi.com
The practising clinician treating a patient with metastatic clear cell renal cell carcinoma
(CCRCC) faces a difficult task of choosing the most appropriate therapeutic regimen in a …

Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma

A Ingels, R Campi, U Capitanio, D Amparore… - Nature Reviews …, 2022 - nature.com
Standard-of-care management of renal cell carcinoma (RCC) indisputably relies on surgery
for low-risk localized tumours and systemic treatment for poor-prognosis metastatic disease …

Upfront cytoreductive nephrectomy for metastatic renal cell carcinoma treated with immune checkpoint inhibitors or targeted therapy: an observational study from the …

Z Bakouny, T El Zarif, S Dudani, JC Wells, CL Gan… - European urology, 2023 - Elsevier
Background The role of upfront cytoreductive nephrectomy (CN) for metastatic renal cell
carcinoma (mRCC) in the era of immune checkpoint inhibitors is unclear. Objective To …

Head-to-head comparison of all the prognostic models recommended by the European Association of Urology Guidelines to predict oncologic outcomes in patients …

G Rosiello, A Larcher, G Fallara… - … Oncology: Seminars and …, 2022 - Elsevier
Abstract Objectives European Urology Association guidelines suggest the use of integrated
prognostic systems to assess oncologic outcomes after surgery in patients with localized …

Development of a novel risk score to select the optimal candidate for cytoreductive nephrectomy among patients with metastatic renal cell carcinoma. results from a …

M Marchioni, M Kriegmair, M Heck, T Amiel… - European urology …, 2021 - Elsevier
Background Selection of patients for upfront cytoreductive nephrectomy (CN) in metastatic
renal cell carcinoma (mRCC) has to be improved. Objective To evaluate a new scoring …

Rates and predictors of perioperative complications in cytoreductive nephrectomy: analysis of the registry for metastatic renal cell carcinoma

E Roussel, R Campi, A Larcher, A Verbiest… - European urology …, 2020 - Elsevier
Background Cytoreductive nephrectomy (CN) plays an important role in the treatment of a
subgroup of metastatic renal cell carcinoma (mRCC) patients. Objective We aimed to …

[HTML][HTML] Treatment strategies for clear cell renal cell carcinoma: Past, present and future

J Yang, K Wang, Z Yang - Frontiers in Oncology, 2023 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney
cancer, which is prone to metastasis, recurrence, and resistance to radiotherapy and …

Sorafenib versus observation following radical metastasectomy for clear-cell renal cell carcinoma: results from the phase 2 randomized open-label RESORT study

G Procopio, G Apollonio, F Cognetti, R Miceli… - European Urology …, 2019 - Elsevier
Background In selected metastatic renal cell carcinoma (mRCC) patients, radical
metastasectomy followed by observation is a potential strategy. It is still to be defined …

[HTML][HTML] Synchronous versus metachronous metastatic disease: impact of time to metastasis on patient outcome—results from the International Metastatic Renal Cell …

F Donskov, W Xie, A Overby, JC Wells… - European urology …, 2020 - Elsevier
Background Patients with metastatic renal cell carcinoma (mRCC) may present with primary
metastases (synchronous disease) or develop metastases during follow-up (metachronous …

Cytoreductive nephrectomy in metastatic patients with signs or symptoms: implications for renal cell carcinoma guidelines

A Larcher, G Fallara, G Rosiello, C Re, G Baiamonte… - European Urology, 2020 - Elsevier
The role of cytoreductive nephrectomy (CN) patients with metastatic renal cell carcinoma
(mRCC) is unclear. To define the proportion of symptomatic mRCC, to investigate the impact …