Copper (Cu) and other transition metals are essential for living organisms but also toxic
when present in excess. To cope with this apparent paradox, organisms have developed …

Glioblastoma (GBM) is a fatal disease with recurrences often associated with
radioresistance. Although often effective at treating newly diagnosed GBM, increasing …

In recent years, with the continuous in-depth exploration of the molecular mechanisms of
tumorigenesis, numerous potential new targets for cancer treatment have been identified …

Oxidative phosphorylation is a tightly regulated process in mammals that takes place in and
across the inner mitochondrial membrane and consists of the electron transport chain and …

COX17 is a soluble protein from the mitochondrial intermembrane space that participates in
the transfer of copper for cytochrome c oxidase (COX) assembly in eukaryotic organisms. In …

Disulfide bond formation drives protein import of most proteins of the mitochondrial
intermembrane space (IMS). The main components of this disulfide relay machinery are the …

The mitochondrial inner membrane is a protein-rich environment containing large multimeric
complexes, including complexes of the mitochondrial electron transport chain, mitochondrial …

Cox17 is an assembly factor that participates in early cytochrome c oxidase (COX, CcO)
assembly stages. Cox17 shuttles copper ions from the cytosol to the mitochondria and …

Oxidative phosphorylation (OXPHOS) in mitochondria takes place at the inner membrane,
which folds into numerous cristae. The stability of cristae depends, among other things, on …

Mitochondrial proteins are frequently acetylated, but most of these modifications are thought
to occur non-enzymatically, rather than requiring an acetyltransferase. A new study by …