The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and
many types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN 3 …

Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …

Despite recent advances in delineating the mechanisms involved in cardiogenesis, cellular
lineage specification remains incompletely understood. To explore the relationship between …

To better understand the relationship between the embryonic hematopoietic and vascular
systems, we investigated the establishment of circulation in mouse embryos by examining …

The goal of the present study was to determine the molecular mechanism whereby
transforming growth factor β (TGFβ) increases smooth muscle (SM) α-actin expression …

Early morphological and biochemical studies indicated that vascular smooth muscle cells
(VSMCs) exhibited two distinct phenotypes and that a change from the contractile to the …

The assembly of the vessel wall from its cellular and extracellular matrix components is a
critical process in the development and maturation of the cardiovascular system. However …

Phenotypic modulation of smooth muscle cells (SMCs) plays an integral role in
atherosclerosis, hypertension and leiomyogenic tumorigenicity. The morphological …

One factor limiting the success of non-viral gene therapy vectors is the relative inability to
target genes specifically to a desired cell type. To address this limitation, we have begun to …