Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

[HTML][HTML] Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis

M El Haj, E Altintas, G Chapelet, D Kapogiannis… - Psychiatry …, 2020 - Elsevier
To cope with Covid-19 and limits its spread among residents, retirement homes have
prohibited physical contact between residents and families and friend and, in some cases …

The prevalence and incidence of early‐onset dementia among adults with autism spectrum disorder

G Vivanti, S Tao, K Lyall, DL Robins… - Autism Research, 2021 - Wiley Online Library
The prevalence and incidence of early‐onset dementia among adults with autism spectrum
disorder (ASD) is currently unknown. In this case–control study, the prevalence and …

Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: Link between type 2 diabetes and Alzheimer's disease

SK Rad, A Arya, H Karimian, P Madhavan… - Drug design …, 2018 - Taylor & Francis
The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer's
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …

Stress-induced depression and Alzheimer's disease: focus on astrocytes

OV Dolotov, LS Inozemtseva, NF Myasoedov… - International journal of …, 2022 - mdpi.com
Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

Panax notoginseng saponins: a review of its mechanisms of antidepressant or anxiolytic effects and network analysis on phytochemistry and pharmacology

W Xie, X Meng, Y Zhai, P Zhou, T Ye, Z Wang, G Sun… - Molecules, 2018 - mdpi.com
Panax notoginseng (Burk) FH Chen, as traditional Chinese medicine, has a long history of
high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet …

Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

MA Hill, SC Gammie - Scientific reports, 2022 - nature.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects multiple
brain regions and is difficult to treat. In this study we used 22 AD large-scale gene …

The phosphodiesterase-4 inhibitor roflumilast, a potential treatment for the comorbidity of memory loss and depression in Alzheimer's disease: a preclinical study in …

H Wang, F Zhang, Y Xu, H Fu, X Wang… - International Journal …, 2020 - academic.oup.com
Background Depression is highly related to Alzheimer's disease (AD), yet no effective
treatment is available. Phosphodiesterase-4 (PDE4) has been considered a promising …

[图书][B] Neuropsychology: From theory to practice

D Andrewes - 2015 - taylorfrancis.com
The second edition of this comprehensive textbook for students of Neuropsychology gives a
thorough overview of the complex relationship between brain and behaviour. With an …