The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide,
producing a number of intermediary metabolites, including 3-hydroxy kynurenine and …

Stress is a multimodal response involving the coordination of numerous body systems in
order to maximize the chance of survival. However, long term activation of the stress …

Depression is a common co-morbidity seen in people with Alzheimer's disease (AD).
However, the successful treatment of depressive symptoms in people with AD is rarely seen …

This study aimed to observe the effects of Tanshinone IIA (Tan IIA) treatment on the
expression levels of brain tissue NeuN, Nissl body, IκB, GFAP and NF-κB in Alzheimer's …

Studies have shown that functional abnormalities in the locus coeruleus (LC) are strongly
associated with depressive symptoms, but the pattern of LC functional connectivity in …

Depression is among the most frequent psychiatric comorbid conditions in Alzheimer
disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big …

Background: The Yizhiqinxin formula (YZQX) has been used to treat Alzheimer's disease
(AD) or major depression disorder (MDD). However, its specific underlying mechanisms and …

Background Alzheimer's disease (AD) is a chronic neurodegenerative disease
characterized by progressive cognitive dysfunctions and behavioral impairments. Patchouli …

Sex differences are important to consider when studying different psychiatric,
neurodevelopmental, and neurodegenerative disorders, including Alzheimer's disease (AD) …

A doença de Alzheimer é o tipo de demência que mais prevalece entre os idosos no
mundo. Para avaliar a evolução da mortalidade por doença de Alzheimer no Brasil foi …