No single animal model can recapitulate all the features of a particular human disease on its
own. Historically, rats have been used to study neurobiology and underlying functional …

Background: Neuropsychiatric symptoms (NPS) among cognitively normal older adults are
increasingly recognized as risk factors for cognitive decline and impairment. However, the …

Serotonin plays a key role in mood or affect, and dysfunction of the serotonin system has
been linked to depression in humans and animal models. Depression appears prior to or …

Background: Both late-life depression (LLD) and short sleep duration increase the risk of
cognitive impairment. Increased insular resting-state functional connectivity (FC) has been …

Abstract Introduction Depression commonly accompanies Alzheimer's disease, but the
nature of this association remains uncertain. Methods Longitudinal data from the COSMIC …

Anxiety is a common symptom among patients with cognitive impairment. The presence of
anxiety is correlated with poorer outcomes; despite this, there is limited research on anxiety …

Octylseleno-xylofuranoside (OSX) is an organic selenium compound which has previously
shown antioxidant and antidepressant-like activities, trough the modulation of …

Background: Increasing concern around perceived neurocognitive decline is increasing the
number of referrals to specialists and anxiety for patients. We aimed to explore the likelihood …

Abstract We asked 44 French and 42 Lebanese participants with Alzheimer's disease (AD)
who lived in their own homes to rate their depression and anxiety during the late fall/early …

Depression is a common neuropsychiatric manifestation among Alzheimer's disease (AD)
patients. It may compromise everyday activities and lead to a faster cognitive decline as well …