Recurrent or persistent infection is the major manifestation of primary immunodeficiency,
which also results in atypical infection with opportunistic organisms. Young children are also …

OBJECTIVES: Common variable immunodeficiency (CVID) is associated with a spectrum of
autoimmune complications. We studied the prevalence of gastrointestinal (GI) …

Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human
immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B …

Primary immunodeficiencies (PIDs) are characterized by an increased susceptibility to
infections due to defects in one ore more components of the immune system. Although most …

Coexisting morbidities in CVID include bronchiectasis, autoimmunity and malignancies. The
incidence of autoimmune disease in CVID patients may approach 20% of cases. The most …

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases
affecting the innate and adaptive immune systems that confer susceptibility to infection …

Background A subset of patients with chronic rhinosinusitis (CRS) has refractory disease.
The risk factors for refractory CRS include atopy, a disrupted mucociliary transport system …

Introduction Common variable immunodeficiency (CVID) is the most prevalent symptomatic
primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial …

Background Common variable immunodeficiency may be complicated by interstitial lung
disease, which leads to worsened morbidity and mortality in some. Although …

SARS-CoV-2 vaccination is the standard of care for the prevention of COVID-19 disease.
Although vaccination triggers both humoral and cellular immune response, COVID-19 …