The vast majority of patients suffering from a primary immunodeficiency (PID) have defects in
their T-and/or B-cell compartments. Despite advances in molecular diagnostics, in many …

Common Variable Immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are
primary antibody deficiencies characterized by hypogammaglobulinemia and recurrent …

Long-term prophylactic antibiotics are being widely implemented as primary or adjunctive
therapy in primary immune deficiencies. This practice has transformed clinical outcomes in …

Objective Common variable immunodeficiency (CVID) is a primary immunodeficiency that is
clinically heterogeneous, characterized by both infectious and noninfectious complications …

Common variable immunodeficiency (CVID) is frequently complicated by the development of
autoimmune and lymphoproliferative diseases. With widespread use of immunoglobulin …

CVID is a genotypically and phenotypically heterogeneous primary immune deficiency, the
genetic and clinical characteristics of which are under active investigation. Further, discovery …

Common variable immunodeficiency (CVID) is a common primary immunodeficiency
characterized by a failure in B-cell differentiation with defective immunoglobulin production …

Inborn errors of immunity (IEI), formerly known as primary immunodeficiency disorders
(PIDs), are inherited disorders caused by damaging germline variants in single genes …

The identification of mutations in the inducible costimulator (ICOS) gene in nine patients with
common variable immunodeficiency (CVID) was a major breakthrough. CVID is a complex …

Common variable immunodeficiency (CVID) is a diagnostic category of primary
immunodeficiency (PID) which may present with heterogeneous disorders including …