This review provides an overview of the changing US epidemiology of cannabis use and
associated problems. Adults and adolescents increasingly view cannabis as harmless, and …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Background: Increases in prescriptions of opioid medications for chronic pain have been
accompanied by increases in opioid overdoses, abuse, and other harms and uncertainty …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Background & Aims Central neuromodulators (antidepressants, antipsychotics, and other
central nervous system− targeted medications) are increasingly used for treatment of …

The purpose of this comprehensive review is to describe various aspects of crisis of opioid
use in the United States. The obstacles that must be surmounted are primarily inappropriate …

Background Long-term efficacy of opioids for non-cancer pain is unproven, but risks argue
for cautious prescribing. Few data suggest how long or how much opioid can be prescribed …

Objective. Previous studies examining opioid dose and overdose risk provide limited
granularity by milligram strength and instead rely on thresholds. We quantify dose …

We review evidence of determinants contributing to increased opioid-related mortality in the
United States and Canada between 1990 and 2013. We identified 17 determinants of opioid …

Importance The unprecedented increase in unintentional overdose events that has occurred
in tandem with escalating sales of prescription opioids over the past 2 decades has raised …