DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Therapy-related myelodysplastic syndromes (t-MDS) represent a heterogeneous group of
malignancies that arise as a late complication of prior exposure to chemotherapy and/or …

Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of
patients with cancer. To explore the value of whole-genome sequencing (WGS) in …

Background: Urothelial bladder carcinomas had traditionally been difficult to treat cancers,
with high morbidity and mortality rates when invasive and metastatic. In recent years …

Co-inhibitory immune checkpoints play a crucial role in tumor progression, and PD-1/PD-L1
inhibitor has been a breakthrough for treating multiple refractory tumors in last decade …

Different types of therapy are currently being used to treat non-small cell lung cancer
(NSCLC) depending on the stage of tumor and the presence of potentially druggable …

Sensitive and specific detection of single nucleotide variants (SNVs) has great potential for
disease diagnosis and prognosis. Hybridization probes based on DNA strand displacement …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal
cancers worldwide, with a poor prognosis and an increasing incidence. Recently, the tumor …

Background After surgical resection of pancreatic ductal adenocarcinoma (PDAC), patients
are predominantly treated with adjuvant chemotherapy, commonly consisting of gemcitabine …