Vanadium is a transition metal that, being ubiquitously distributed in soil, crude oil, water
and air, also found roles in biological systems and is an essential element in most living …

A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

Background: Chagas Disease is a neglected tropical disease caused by the protozoan
Trypanosoma cruzi, with some of the most serious manifestations affecting the …

Chagas disease, a chronic systemic parasitosis caused by the Kinetoplastid protozoon
Trypanosoma cruzi, is the first cause of cardiac morbidity and mortality in poor rural and …

Tropical diseases today constitute a major health problem and a big challenge for drug
discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent …

Background. Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance
and safety data in adults are scarce. We aimed to evaluate nifurtimox tolerance and safety in …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Research efforts on the medicinal chemistry of vanadium have been mainly focused whether
on improving biodistribution and tolerability of the vanadium insulin-enhancing core or on …

In the next five years, we can now project that 200,000 people living with Chagas disease
will die from heart disease and related complications. We urgently need to redouble our …

A hundred years from its description, Chagas cardiomyopathy remains a challenging
disease. Although successful vector-control strategies have decreased the incidence of …