The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Endocannabinoids (eCBs) are lipid-based retrograde messengers with a relatively short half-
life that are produced endogenously and, upon binding to the primary cannabinoid receptors …

The endocannabinoid system is involved in signal transduction in mammals. It comprises
principally G protein-coupled cannabinoid receptors and their endogenous agonists, called …

Abstract Amidases (EC 3. 5. 1. X) are versatile biocatalysts for synthesis of chiral carboxylic
acids, α-amino acids and amides due to their hydrolytic and acyl transfer activity towards the …

Conspectus Signaling lipids, such as the endocannabinoids, play an important role in the
brain. They regulate synaptic transmission and control various neurophysiological …

The endocannabinoid system (ECS) is a widespread cell signaling network that maintains
homeostasis in response to endogenous and exogenous stressors. This has made the ECS …

Chronic pain affects 1.5 billion people worldwide but remains woefully undertreated.
Understanding the molecular events leading to its emergence is necessary to discover …

Background and Purpose Devising novel strategies to therapeutically favour inflammation
resolution and provide neuroprotection is an unmet clinical need. Enhancing …

Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …