The membrane steps of bacterial cell wall synthesis as antibiotic targets

Y Liu, E Breukink - Antibiotics, 2016 - mdpi.com
Peptidoglycan is the major component of the cell envelope of virtually all bacteria. It has
structural roles and acts as a selective sieve for molecules from the outer environment …

Glycosyltransferase-catalyzed synthesis of bioactive oligosaccharides

CAGM Weijers, MCR Franssen, GM Visser - Biotechnology advances, 2008 - Elsevier
Mammalian cell surfaces are all covered with bioactive oligosaccharides which play an
important role in molecular recognition events such as immune recognition, cell–cell …

Crystal structure of the MurG: UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases

Y Hu, L Chen, S Ha, B Gross… - Proceedings of the …, 2003 - National Acad Sciences
MurG is an essential glycosyltransferase that forms the glycosidic linkage between N-acetyl
muramyl pentapeptide and N-acetyl glucosamine in the biosynthesis of the bacterial cell …

[PDF][PDF] Remarkable structural similarities between diverse glycosyltransferases

Y Hu, S Walker - Chemistry & biology, 2002 - cell.com
From a functional standpoint, glycosyltransferases (GTases) comprise one the most diverse
group of enzymes in existence. Every category of biopolymer (oligosaccharides, proteins …

Enzyme-catalyzed processes in pharmaceutical industry

JP Rasor, E Voss - Applied Catalysis A: General, 2001 - Elsevier
Biocatalysis is enjoying an increasing interest not only in academia, but also in industry. It
has been the topic of several excellent reviews or books [Bornscheuer and Kaszlauskas …

Biocatalytic synthesis of oligosaccharides

MM Palcic - Current opinion in biotechnology, 1999 - Elsevier
Tremendous advances in biocatalytic approaches to oligosaccharide synthesis have taken
place in the past two years. The use of isolated enzymes, both glycosyltransferases and …

Microwave-assisted synthesis of galacto-oligosaccharides from lactose with immobilized β-galactosidase from Kluyveromyces lactis

T Maugard, D Gaunt, MD Legoy, T Besson - Biotechnology Letters, 2003 - Springer
Galacto-oligosaccharides (GOS) were synthesized from lactose by immobilized and free β-
galactosidase from Kluyveromyces lactis (Lactozym 3000 L HP-G) using either focused …

[图书][B] Polymeric biomaterials

S Dumitriu, VI Popa - 2013 - books.google.com
Biomaterials have had a major impact on the practice of contemporary medicine and patient
care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers …

Large-scale production of oligosaccharides using engineered bacteria

T Endo, S Koizumi - Current opinion in structural biology, 2000 - Elsevier
Rapid advances in the cloning and expression of glycosyltransferase genes, especially from
bacteria, could open the way to overcoming difficulties in the mass production of …

Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency

M Yang, MR Proctor, DN Bolam, JC Errey… - Journal of the …, 2005 - ACS Publications
The glycan portion of macrolide antibiotics modulates their efficacy. High-level expression of
three macrolide GTs and kinetic analysis has revealed a highly selective synthetic “tool kit” …