Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

MS Hussain, O Afzal, G Kumar, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …

Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review

MS Hussain, G Gupta, M Afzal, SM Alqahtani… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression,
contributing significantly to a diverse range of cellular processes, including apoptosis. One …

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

C Adriaens, L Standaert, J Barra, M Latil, A Verfaillie… - Nature medicine, 2016 - nature.com
In a search for mediators of the p53 tumor suppressor pathway, which induces pleiotropic
and often antagonistic cellular responses, we identified the long noncoding RNA (lncRNA) …

Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness

VY Shin, J Chen, IWY Cheuk, MT Siu, CW Ho… - Cell death & …, 2019 - nature.com
Triple-negative breast cancer (TNBC) is a malignant subtype of breast cancer with the
absence of targeted therapy, resulting in poor prognosis in patients. Chemotherapy remains …

Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors

P Dong, Y Xiong, J Yue, SJB Hanley… - Frontiers in …, 2018 - frontiersin.org
The nuclear paraspeckle assembly transcript 1 (NEAT1, a long non-coding RNA) is
frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with …

Current status and perspective biomarkers in AFP negative HCC: towards screening for and diagnosing hepatocellular carcinoma at an earlier stage

P Luo, S Wu, Y Yu, X Ming, S Li, X Zuo, J Tu - Pathology & Oncology …, 2020 - Springer
Hepatocellular carcinoma (HCC) is one of the most malignant cancer with high morbidity
and mortality which lead to a serious burden to society. AFP (alpha-fetoprotein) is the most …

NEAT 1: A novel cancer‐related long non‐coding RNA

X Yu, Z Li, H Zheng, MTV Chan, WKK Wu - Cell proliferation, 2017 - Wiley Online Library
Aberrant overexpression of the long non‐coding RNA NEAT 1 (nuclear paraspeckle
assembly transcript 1) has been documented in different types of solid tumours, such as lung …

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

S Dhamija, S Diederichs - International journal of cancer, 2016 - Wiley Online Library
Metastasis is a multistep process that involves the dissemination of cells from the primary
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …