1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

The preparation methods and reactions of isoxazoles are described and systematized on
the basis of analysis of the literature published from 2005 to present. In the discussion of …

Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated
protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction …

Heterocyclic substances perform a very unique role in drug design and discovery. This
article provides the primary objectives of the analysis within pyrimidine centered new …

In the present study, we report the exploration of binding modes of potent HIV-1 integrase
(IN) inhibitors MK-0518 (raltegravir) and GS-9137 (elvitegravir) as well as chalcone and …

Novel derivatives of pyrazino [2, 1‐a] isoindolediones were synthesized through 6‐exo‐dig
intramolecular hydroamination of 2, 3‐dihydro‐3‐oxo‐2‐(prop‐2‐yn‐1‐yl)‐1H‐isoindole‐1 …

In the present study, 199 compounds derived from pyrimidine, pyrimidone and
pyridopyrazine carboxamides with inhibitory activity against HIV-1 integrase were modeled …

A series of 5, 6-dihydroxypyrimidine analogs were synthesized and evaluated for their anti-
HIV activity in vitro. Among all of the analogs, several compounds exhibited significant anti …

The development of new and safe anti-human immunodeficiency virus (anti-HIV) drugs has
been an urgent task for medical research recently. Herein, based on the norm-index …