The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Exosomes are attractive as nucleic-acid carriers because of their favourable
pharmacokinetic and immunological properties and their ability to penetrate physiological …

The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …

Exosomes have emerged as a promising cell-free therapeutic approach. However,
challenges in large-scale production, quality control, and heterogeneity must be overcome …

Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …